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Emmanuel Compe Selected Research

Trichothiodystrophy Syndromes

1/2021Reduced levels of prostaglandin I2 synthase: a distinctive feature of the cancer-free trichothiodystrophy.
1/2019TFIIE orchestrates the recruitment of the TFIIH kinase module at promoter before release during transcription.
2/2015TFIIH-dependent MMP-1 overexpression in trichothiodystrophy leads to extracellular matrix alterations in patient skin.
10/2014Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy.
8/2013Abnormal XPD-induced nuclear receptor transactivation in DNA repair disorders: trichothiodystrophy and xeroderma pigmentosum.
3/2013XPD mutations in trichothiodystrophy hamper collagen VI expression and reveal a role of TFIIH in transcription derepression.
11/2007Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH.

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Emmanuel Compe Research Topics

Disease

7Trichothiodystrophy Syndromes
01/2021 - 11/2007
5Xeroderma Pigmentosum (Kaposi's Disease)
01/2021 - 12/2009
3Neoplasms (Cancer)
01/2021 - 02/2015
2Inborn Genetic Diseases (Disease, Hereditary)
12/2009 - 11/2007
1Melanoma (Melanoma, Malignant)
01/2021
1Lamellar Ichthyosis (Harlequin Ichthyosis)
03/2020
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
10/2016
1Skin Neoplasms (Skin Cancer)
08/2013
1Microcephaly
11/2007
1Congenital Hypothyroidism (Cretinism)
07/2007
1Cockayne Syndrome (Syndrome, Cockayne)
04/2007
1Necrosis
12/2004
1Lipodystrophy
01/2002

Drug/Important Bio-Agent (IBA)

5Transcription Factor TFIIHIBA
01/2021 - 11/2007
2Proteins (Proteins, Gene)FDA Link
01/2021 - 10/2016
2Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
08/2013 - 04/2007
1Epoprostenol (Prostacyclin)FDA LinkGeneric
01/2021
1CholesterolIBA
03/2020
1Liver X ReceptorsIBA
03/2020
1transcription factor TFIIE (TFIIE)IBA
01/2019
1Pharmaceutical PreparationsIBA
10/2016
1PM 01183IBA
10/2016
1Proteasome Endopeptidase Complex (Proteasome)IBA
10/2016
1UbiquitinIBA
10/2016
1DNA (Deoxyribonucleic Acid)IBA
10/2016
1RNA Polymerase II (RNA Polymerase B)IBA
10/2016
1Sirtuin 1IBA
10/2014
1SulfurIBA
08/2013
1CollagenIBA
03/2013
1Phosphotransferases (Kinase)IBA
02/2011
1A-Form DNA (A-DNA)IBA
11/2007
1Hormones (Hormone)IBA
07/2007
1Reactive Oxygen Species (Oxygen Radicals)IBA
12/2004
1Nelfinavir (Viracept)FDA Link
12/2004
1Protease Inhibitors (Protease Inhibitor)IBA
01/2002
1Reverse Transcriptase InhibitorsIBA
01/2002
1NucleosidesIBA
01/2002

Therapy/Procedure

2Therapeutics
01/2021 - 10/2016
1Highly Active Antiretroviral Therapy (HAART)
01/2002